|Azteca Stadium – Mon, 11/21|
Arizona and San Francisco will play in Mexico City on Monday Night Football, pitting a 5-4 Niners squad against a 4-6 Cardinals unit. The 49ers are 3-2 over their past five and have won consecutive games. The Cardinals are 2-3 over the same span after defeating the Rams last week at home. The kickoff from Estadio Azteca will be at 8:15 pm EDT. San Francisco is an eight-point spread favorite, and the game total is 43.5 points.